The first report of human primary thoracic spine mast cell sarcoma: a case report. Ali C. Ravanpay, Jonathan R. Fromm, Kerstin L. Edlefsen, Paul Martin, and Randal Chesnut. Clinical Neuropathology, Vol. Ravanpay 1 4Jonathan R. Fromm 2Kerstin L. Mast cell sarcoma is an aggressive and rare cancer. To date, no cases of primary mast cell sarcoma have been reported in the spinal vertebrae. The patient initially presented with a 1-month history of pelvic and abdominal pain. Inconclusive gynecological evaluation resulted in a CT of the abdomen and pelvis, demonstrating a destructive lesion Sextreff I Oslo Japanese Dating Site at the 11 th thoracic vertebral body. The patient underwent a two-stage spine operation for T11 corpectomy and T7-L3 posterior spinal fusion. Histopathological, immunohistochemical, and flow cytometry studies of the resection specimens showed the tumor to be mostly composed of CDpositive and mast cell tryptase-positive cells with features consistent with mast cell sarcoma. This is the first reported case of primary vertebral mast cell sarcoma, which may mimic other destructive lesions of the spine including osteomyelitis, vertebral tuberculosis, or plasmacytoma. Correspondence to: Ali C. Ravanpay, MD, PhD Department of Neurological Surgery University of Washington 9th Ave. BoxSeattle, WAUSA Email: [email protected]. Protective effect of combined application of taurine and 3-hydroxy-1,2-dimethylpyridone on metal elements and neurotransmitters in brain after aluminum poisoning in rats. Trace Elements and Electrolytes, Vol. The drugs were given via oral gavage. The contents of metal elements in the brain were detected by inductively coupled plasma-atomic emission spectrometry ICP-AESand the content of monoamine neurotransmitters and amino acid neurotransmitters in the brain were detected by high-performance liquid chromatography HPLC. Results: Al intake caused a significant increase of Al and Zn but a reduction of Mg and Cu in rat brain p Conclusion: Both Tau and DFP contribute to excrete excess Al and regulate element balance in brain, and to improve the brain neurotransmitter disorder of rats exposed to Al. The combination of Tau and DFP may have neuroprotectives effect on Al-induced nervous dysfunction in rats. Correspondence to: Prof. Amr El-Husseini, Amit Chakraborty, Qingcong Yuan, Saqib Inayatullah, Heather Bush, and B. Peter Sawaya. Clinical Nephrology, Vol. Peter Sawaya 1 1 Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington, KY, USA, 2 Division of Nephrology, Mansoura University, Mansoura, Egypt, and 3 Department of Statistics, University of Kentucky, Lexington, KY, USA Introduction: It is well documented that patients with osteoporosis OP have high incidence of hypercalciuria HC. However, the mechanism of HC in patients with OP is not well established. It is thought to be the result of high bone turnover HBT with excessive bone resorption. OP also frequently presents with low bone turnover LBT. At this time, it is not clear whether OP with LBT is also associated with hypercalciuria. Purpose: The purpose of this study is to evaluate urinary calcium excretion in osteoporotic patients with HBT and LBT. Materials and methods: This is a retrospective study of patients with osteoporosis who underwent bone biopsy at the University of Kentucky between January and December Based on bone biopsy results, patients were divided into HBT or LBT groups. Also, intact parathyroid hormone iPTHserum osteocalcin, bone-specific alkaline phosphatase, N-telopeptide of type I collagen, and urine pyridinium levels were measured. Results: Hypercalciuria was present in approximately half of the patients in both the HBT and LBT groups. There was no difference between HBT and LBT Sextreff I Oslo Japanese Dating Site in hour urinary calcium excretion, serum creatinine, calcium, phosphorus, eGFR, filtered calcium load, and fractional excretion of phosphorus. There was a significant correlation between filtered calcium load and urinary calcium excretion in HBT patients but not in patients with LBT. Fractional excretion of calcium significantly correlated with urinary calcium excretion in both groups.
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